![]() GBM often recurs 7-9 months after resection of the primary tumor, at which point the tumor is often non-resectable, and poorly responsive to chemo- and/or radiotherapy, leaving patients with therapeutic options limited to clinical trial enrollment (van Linde, M. Despite an aggressive standard of care (SoC) including maximal surgical resection and chemoradiotherapy, GBM patients have a median survival time of less than 15 months, and a five-year survival rate of less than 6.8% ( Stupp et al. Glioblastoma (GBM) is the most common malignant brain tumor in adults accounting for approximately 14.6% of all brain tumors ( Ostrom et al.
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